Hexokinases phosphorylate glucose to produce glucose-6-phosphate， thus committing glucose to the glycolytic pathway. Alternative splicing of Glucokinase results in three tissue-specific forms of glucokinase， one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase， HK4 is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus （NIDDM）， maturity onset diabetes of the young， type 2 （MODY2） and persistent hyperinsulinemic hypoglycemia of infancy （PHHI）.
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大肠杆菌中重组表达
溶解建议
提供的人己糖激酶-4（GCK）产品为过滤灭菌的无色溶液；其中1mg/ml人己糖激酶-4（GCK）产品溶解于20mM Tris pH 8.0，10%甘油溶液中.
