MAP kinase-activated protein kinase 3 （MAPKAPK3） is involved in inflammatory Reaction by regulating tumor necrosis factor （TNF） and IL6 production post-transcriptionally. MAPKAPK3 phosphorylates AU-rich elements （AREs）-binding proteins， like TTP/ZFP36， leading to control of stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36 （a major post-transcriptional regulator of TNF）， promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity resulting in inhibition of dependent degradation of ARE-containing transcript. MAPKAPK3 is activated by growth inducers and stress stimulation of cells.
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大肠杆菌中重组表达.
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提供的重组人促分裂素原活化蛋白激酶激活的蛋白激酶3产品形式为无菌的无色溶液.
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建议将重组人促分裂素原活化蛋白激酶激活的蛋白激酶3产品整瓶保存于4℃可保存2-4周. 长期保存，请置于-20℃.长期保存，推荐添加载体蛋白 （0.1% HSA or BSA）.请避免反复冻融.
