5’-AMP-activated protein kinase subunit beta-1 (PRKAB1) hinders protein, carbohydrate and lipid biosynthesis, in addition to cell growth and proliferation. AMPK is a heterotrimer comprised of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK acts via direct phosphorylation of metabolic enzymes, and longer-term effects by phosphorylation of transcription regulators. PRKAB1 is a regulator of cellular polarity by remodeling the actin cytoskeleton; most likely by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex compiles, through its C-terminus that joins alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
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来源宿主
大肠杆菌中重组表达.
溶解建议
提供的重组人腺苷单磷酸活化蛋白激酶B1(非催化亚基)产品形式为无菌的无色溶液.
保存建议
建议将重组人腺苷单磷酸活化蛋白激酶B1(非催化亚基)产品整瓶保存于4℃可保存2-4周. 长期保存,请置于-20℃.长期保存,推荐添加载体蛋白 (0.1% HSA or BSA).请避免反复冻融.