In plants, clathrin-mediated endocytosis (CME) is dependent on the function of clathrin and its accessory heterooligomeric adaptor protein complexes, ADAPTOR PROTEIN2 (AP-2) and the TPLATE complex (TPC) , and is negatively regulated By the hormones auxin and salicylic acid (SA) . The AP-2 complex has Been generally thought to function as a heterotetramer, consisting of two large (a/A and B/B) ( At4G11380) , one medium (m/M) ( At5g46630) , and one small (s/S) ( At1g47830) suBunit(s) .
