CBR4 belongs to the short-chain dehydrogenase/reductase family. The formation of heteroteramer
with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity for o- and p-quinones. It
plays a role in biosynthesis of fatty acids in mitochondria and has broad substrate specificity and reduces 9,10-
phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). Recombinant
human CBR4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional
chromatography techniques
序列
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溶解建议
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