BAIAP2 is a ubiquitous regulator of the actin cytoskeleton. Controlled by the Rho-family GTPases BAIAP2 facilitates filopodia development. BAIAP2 is expressed in the cytoplasm and binds small membrane-bound G-proteins to cytoplasmic effector proteins and operates as an insulin receptor tyrosine kinase substrate. BAIAP2 proposes a part for insulin in the central nervous system and was identified as interacting with the dentatorubral pallidoluysian atrophy gene, which is related to an autosomal dominant neurodegenerative disease.
序列
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来源宿主
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溶解建议
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex.
