Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of Cyclin-Dependent Kinase Inhibitor 2A steadily increases with age, and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the Cyclin-Dependent Kinase Inhibitor 2A gene is frequently found in melanomas, as well as in certain other types of cancer. TAT is a cell penetrating peptides (CPPs) and was shown to enable the introduction of nucleic acids into cells.
序列
提供的细胞周期蛋白依赖性激酶抑制剂2A_TAT，人类重组Cyclin-dependent kinase inhibitor 2A_TAT, Human Recombinant是Biovision品牌中国区域总代理艾美捷科技产品，具体的蛋白序列可查看提供的英文版本产品说明书。
来源宿主
提供的细胞周期蛋白依赖性激酶抑制剂2A_TAT，人类重组Cyclin-dependent kinase inhibitor 2A_TAT, Human Recombinant产品来源宿主，查看该产品说明书，或者在线咨询我们。
溶解建议
Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. Do not vortex. Additional carrier protein (example 0.1% BSA) is recommended for long term storage.
