- 中文名称
用于开发夹心ELISA试剂盒,以测定细胞培养上清液、细胞裂解物、血清和血浆(肝素、EDTA)中的人IGFBP3。
- 英文名字
- For the development of sandwich ELISA kit to measure human IGFBP3 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).
- 供应商
- Nordic BioSite
- 产品货号
- NDC-KBB-BLRDKB-5
- 产品报价
- ¥询价/5plates

- 产品说明书
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- 购买方式
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- 产品新闻

- 背景资料
- Insulin-like growth factor(IGF)-binding protein-3(IGFBP-3) is a major determinant of circulating levels of the IGFs and is clinically useful for the evaluation of GH deficiency and for predicting the response to GH treatment. The circulating level of IGFBP-3 is inversely related to the risk of several common cancers, and that antiproliferative agents such as antiestrogens and retinoids act in part by up-regulating IGFBP-3 gene(IGFBP3) expression. Insulin-like growth factor-binding protein(IGFBP)-3, well characterized as the carrier of insulin-like growth factor(IGF), has been reported to have intrinsic bioactivity that is independent of IGF binding. IGFBP-3 has an IGF-independent, antiproliferative effect in undifferentiated and early differentiated but not in terminally differentiated chondrocytes. IGFBP-3 possesses both growth-inhibitory and potentiating effects on cells that are independent of IGF action and are mediated through specific. IGFBP-3 binding proteins/receptors locate at the cell membrane, cytosol, or nuclear compartments and in the extrIGFBP-3llular matrix. IGFBP3 is also located on chromosome 7. The standard product used in this kit is recombinant human IGFBP-3, consisting of 265 amino acids with the molecular mass of 29kDa. As a result of glycosylation, the molecular mass is 41KDa.
- 产品描述
- 胰岛素样生长因子(IGF)结合蛋白-3(IGFBP-3)是IGF循环水平的主要决定因素,在临床上可用于评估GH缺乏和预测GH治疗的反应。IGFBP-3的循环水平与几种常见癌症的风险负相关,并且抗增殖剂如抗雌激素和类维生素A部分地通过上调IGFBP-3基因(IGFBP 3)表达而起作用。胰岛素样生长因子结合蛋白(IGFBP)-3是胰岛素样生长因子(IGF)的载体,具有与IGF结合无关的生物活性。IGFBP-3在未分化和早期分化的软骨细胞中具有IGF非依赖性抗增殖作用,但在终末分化的软骨细胞中没有。IGFBP-3对细胞具有生长抑制和增强作用,这些作用不依赖于IGF作用,并通过特异性的。IGFBP-3结合蛋白/受体位于细胞膜、胞质溶胶或核区室以及IGFBP-3细胞外基质中。IGFBP 3也位于7号染色体上。本试剂盒使用的标准品为重组人IGFBP-3,由265个氨基酸组成,分子量为29 kDa。由于糖基化,分子量为41 KDa。
- 产品特点
- F-TESTO(游离睾酮)ELISA试剂盒
- 保存建议
- -20°C
- 其他
- Nordic BioSite(北欧生物) 总部位于瑞典,成立于1997年,旨在分销研究和诊断领域的高质量和创新产品。 Nordic BioSite 被公认为整个北欧生物医学研究和诊断产品领域的领导者。他们拥有超过570万种的产品组合,代理了遍布欧洲和美国的顶级生物试剂制造商,是欧洲知名的一站式生物试剂代理商。除了作为分销商之外,Nordic BioSite 还拥有不断增长的自产产品线——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自产产品线(共26W+产品)。Nordic BioSite的产品类型主要是抗体,蛋白和试剂盒,产品适用范围涵盖15个不同的物种(人,牛,犬,鲶鱼,鸡,海豚,马,猫,豚鼠,小鼠,绵羊,兔子,大鼠,猪和火鸡),可为您提供一站式的生命科学研究解决方案~
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