Endothelial protein C receptor(EPCR) also known as CCCA or PROCR is a protein that in humans is encoded by the PROCR gene. PRPCR gene is mapped to 20q11.2 by radiation hybrid analysis and FISH. The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
产品描述
内皮蛋白C受体（英语：Endothelial protein C receptor，EPCR）也称为CCCA或PROCR，是一种由人类PROCR基因编码的蛋白质。利用辐射杂交和FISH技术将PRPCR基因定位于20q11.2。该基因编码的蛋白质是活化蛋白C的受体，活化蛋白C是一种由凝血途径活化并参与凝血途径的丝氨酸蛋白酶。编码的蛋白质是N-糖基化的I型膜蛋白，其增强蛋白C的活化。该基因的突变与静脉血栓栓塞和心肌梗死以及妊娠期晚期胎儿丢失有关。
