Bmi-1 has been identified as a potent oncogene as it contributes to the transcriptional activation of genes implicated in early lymphoid development. Proviral activation of Bmi-1 expression corresponds to enhanced gene-specific activation of other proto-oncogenes, including c-Myc and Pim, subsequently resulting in the progression of lymphomagenesis.
应用类型
WB,ICC,IHC,FC
免疫原
This antibody is produced by immunizing mice with a recombinant protein corresponding to a region of Bmi1.
