CNOT4 (CCR4 NOT transcription complex subunit 4) has intrinsic E3 ubiquitin ligase activity. Binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective. The CCR4-NOT complex functions as a global regulator of RNA polymerase II transcription.
应用类型
WB,IHC
免疫原
Synthetic peptide, corresponding to amino acids 61-110 of Human CNOT4.
