JNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK1 is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of JNK1 by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. JNK1 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of JNK1 gene suggested that it play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported
应用类型
该Anti-JNK1 (MAPK8)产品的应用类型详情查看产品说明书。
免疫原
Recombinant protein expressed in E.coli corresponding to amino acids 1-384 of human JNK1
来源宿主
mouse
反应性
该Mouse Monoclonal Antibody to CD11a产品的反应性详情查看产品说明书。
