Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator.
应用类型
该抗IFT57（HIPPI）产品的应用类型详情查看产品说明书。
免疫原
Full length human recombinant protein of human IFT57 (NP_060480) produced in HEK293T cell.
