The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
应用类型
该抗XRCC1抗体产品的应用类型详情查看产品说明书。
免疫原
Full length human recombinant protein of human XRCC1 (NP_006288) produced in HEK293T cell.
