Iba1, also designated AIF-1 for allograft inflammatory factor-1, is a cytoplasmic, cytokine-induced, calcium-binding protein first discovered in rat cardiac allografts with chronic rejection. Iba1 is expressed in various human immune-related tissues and may play a role in macrophage activation and function. It is a marker of human microglia and is expressed by macrophages in injured skeletal muscle. Iba1 regulates reduced proliferation and differentiation of satellite cells.
