LAIR-1 is an inhibitory receptor that belongs to the Immunoglobulin superfamily. It has one extracellular Ig-like domain and an intracellular C-terminus with two ITIM (immunoreceptor tyrosine-based inhibitory motif) domains. It is found on peripheral mononuclear cells, including NK, T, and B cells, and is thought to play a negative regulatory role on the cytolytic function of these cells through signaling through collagen ligation. LAIR1 has been noted to be upregulated in renal cell carcinoma, and may play a role in expansion of Th17 cell populations in collagen-rich environments, such as in graft rejection tissue.
应用类型
该CD305 Recombinant Protein产品的应用类型详情查看产品说明书。
免疫原
该CD305 Recombinant Protein产品的免疫原详情查看产品说明书。
来源宿主
bacteria
反应性
该Mouse Monoclonal Antibody to KLF2产品的反应性详情查看产品说明书。
