Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. Belonging to the N/E subfamily, CPXM2 (Inactive carboxypeptidase-like protein X2) is a 756 amino acid protein that contains a F5/8 type C domain and is secreted. Most members of the N/E subfamily contain several domains, including an active carboxypeptidase domain and signal peptide and are thought to function mostly in mediating protein-protein interactions and/or protein-membrane interactions, thereby targeting the protein to specific locations within the secretory pathway. CPXM2 is a unique member of this subfamily in that it does not appear to exhibit any enzymatic activity due to lack of several active-site residues that are present in the catalytic domain of other members of the N/E subfamily. Expression of the closely related protein CPXM is regulated during osteoclastogenesis, suggesting that CPXM may play a role in osteoclast differentiation.
应用类型
WB
免疫原
A synthetic peptide corresponding to residues in Human CPXM2.
