PHD2 (Egl nine homolog 1) catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex.
应用类型
IF
免疫原
Recombinant full length Human EGLN1.
来源宿主
该CD200R1产品的来源宿主详情查看产品说明书。
反应性
rabbit
保存建议
该Mouse Monoclonal Antibody to PPARA产品的保存建议详情查看产品说明书。
