E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme,nbinds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissuenspecific transcription, and the adenovirus E1A-associated cellular p300 transcriptionalnco-activator protein. EID-1 inhibits cellular differentiation by blockingnthe histone acetyltransferase activity of p300. EID-1 also acetylates bothnhistones and non-histone proteins such as NCOA3 co-activator. By acetylatingnhistones, EID-1 gives a specific tag for transcriptional activation. In additionnto binding Rb and p300, EID-1 also binds to phosphorylated CREB protein,nmediating cAMP gene regulation. EID-1 augments the activity of phosphorylatednCREB and activates transcription of cAMP responsive genes as anco-activator.
应用类型
WB
免疫原
Synthetic peptide, corresponding to amino acids 70-114 of Human EID1
