Deoxyhypusine synthase (DHS) is crucial for the posttranslational formation of hypusine, a modification of a specific lysine residue in eukaryotic initiation factor 5A (eIF-5A). Hypusine is formed by posttranslational modifications involving two enzymatic steps catalyzed by DHS and deoxyhypusine hydroxylase (DOHH). eIF-5A is essential for eukaryotic cell proliferation. DHS, which belongs to the deoxyhypusine synthase family of proteins, is important for the first step in the hypusine biosynthesis pathway. It acts as a catalyst for the NAD-dependent oxidative cleavage of spermidine and the ensuing transfer of the butylamine moiety of spermidine to the eIF-5A protein, to create the intermediate deoxyhypusine residue.
应用类型
WB
免疫原
Recombinant full length Human DHPS.
来源宿主
该Mouse Monoclonal Antibody to DDX1产品的来源宿主详情查看产品说明书。
反应性
rabbit
保存建议
该Mouse IgG monoclonal antibody for DCK detection. Tested with WB, IHC, FCM in Human.产品的保存建议详情查看产品说明书。
