Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription, SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins directs ubiquitination of BCL2.
应用类型
IF,WB
免疫原
Recombinant fusion protein containing a sequence corresponding to amino acids 500-776 of human Cullin 1 (NP_003583.2).
