This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
应用类型
WB
免疫原
Recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human BUB1B (NP_001202.4).
