May act as a scaffolding protein within caveolar membranes, Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity), Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation, Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner, Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway, Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.
