Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation, Can both act as an activator or a repressor depending on the context, Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1, Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3), The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3), Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.
应用类型
WB
免疫原
Recombinant fusion protein containing a sequence corresponding to amino acids 525-725 of human ATF7IP (NP_060649.3).
