- 中文名称
Anti-EGLN3 antibody (1-120)
- 英文名字
- Anti-EGLN3 antibody (1-120)
- 供应商
- Nordic BioSite
- 产品货号
- NDC-ASJ-42F93O-50
- 产品报价
- ￥询价/50ul
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A, Also hydroxylates HIF2A, Has a preference for the CODD site for both HIF1A and HIF2A, Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site, Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex, Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes, EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia, Also hydroxylates PKM in hypoxia, limiting glycolysis, Under normoxia, hydroxylates and regulates the stability of ADRB2, Regulator of cardiomyocyte and neuronal apoptosis, In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex, In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity, Also essential for hypoxic regulation of neutrophilic inflammation, Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway, Target proteins are preferentially recognized via a LXXLAP motif.
- 应用类型
- IF,IHC,WB
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human PHD3 (NP_071356.1).
- 来源宿主
- rabbit
- 反应性
- human,mouse,rat
- 保存建议
- -20
- 其他
- Nordic BioSite(北欧生物) 总部位于瑞典，成立于1997年，旨在分销研究和诊断领域的高质量和创新产品。 Nordic BioSite 被公认为整个北欧生物医学研究和诊断产品领域的领导者。他们拥有超过570万种的产品组合，代理了遍布欧洲和美国的顶级生物试剂制造商，是欧洲知名的一站式生物试剂代理商。除了作为分销商之外，Nordic BioSite 还拥有不断增长的自产产品线——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自产产品线(共26W+产品)。Nordic BioSite的产品类型主要是抗体，蛋白和试剂盒，产品适用范围涵盖15个不同的物种(人，牛，犬，鲶鱼，鸡，海豚，马，猫，豚鼠，小鼠，绵羊，兔子，大鼠，猪和火鸡)，可为您提供一站式的生命科学研究解决方案~
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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