A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 668 2003). The phosphorylation of APP at Thr is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).
应用类型
WB
免疫原
C-Term|Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
