Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42, Can regulate cell morphology in cooperation with activated RAC1, Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).
应用类型
WB
免疫原
Recombinant fusion protein containing a sequence corresponding to amino acids 60-330 of human DEF6 (NP_071330.3).
