Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA, Regulates FANCD2 monoubiquitination upon DNA damage, Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed, Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
应用类型
WB
免疫原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human C19orf40 (NP_689479.1).
