This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
应用类型
该小鼠抗MDM2单克隆抗体产品的应用类型详情查看产品说明书。
免疫原
Purified recombinant fragment of human MDM2 (AA: 26-169) expressed in E. Coli.
