The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
应用类型
ELISA,IF,IHC,WB
免疫原
DR1-associated protein 1(negative cofactor 2 alpha)
