CD172b, the signal-regulatory protein beta (SIRP beta) is a disulfide-linked homodimer expressed on myeloid cells including monocytes and dendritic cells. Similarly to CD172a, it serves as a negative regulator of tyrosine kinase-coupled signaling processes. Unlike CD172a, the CD172b protein does not possess the cytoplasmic domain, but instead its transmembrane domain can interact with another transmembrane protein DAP-12, which contains ITAM sequences in its intracellular domain and links CD172b to the downstream signaling molecules. The result is e.g. regulation of neutrophil transepithelial migration.
应用类型
FC
免疫原
NIH-3T3 cells transfected with human CD172b
来源宿主
该Mouse IgG monoclonal antibody for CD146/MCAM detection. Tested with WB, IHC, IHC-F, FCM in Human.产品的来源宿主详情查看产品说明书。
