Anhidrotic ectodermal dysplasia(EDA) is an X-linked recessive disorder which affects ectodermal structures. Ectodysplasin-A, the protein encoded by the EDA gene, is a member of the tumor necrosis factor ligand superfamily that forms a collagen triple helix, suggesting functions in signal transduction and cell adhesion. Wnt signaling does control EDA gene expression, but ectodysplasin-A does not feedback on the Wnt pathway.
应用类型
WB
免疫原
A synthetic peptide corresponding to a sequence in the middle region of human EDA(254-269aa HLQGQGSAIQVKNDLS), identical to the related mouse and rat sequences.
