Adenosine triphosphate-binding cassette subfamily B, member 4(ABCB4), also called MDR3, is a protein that in humans is encoded by the ABCB4 gene. MDR1 and MDR3 constitute the human P-glycoprotein gene family. The MDR3 gene contains 28 exons and 27 of these contain coding sequences for the two homologous halves of the protein that correlate with functional domains. MDR3 gene mutations represent a genetic factor involved in this peculiar form of cholesterol gallstone disease in adults.
应用类型
WB
免疫原
A synthetic peptide corresponding to a sequence at the N-terminus of human ABCB4(1-20aa MDLEAAKNGTAWRPTSAEGD).
