CDK5, Cyclin-Dependent Kinase5, is also know as PSSALRE. The p34(CDC2) protein kinase regulates important transitions in the eukaryotic cell cycle. The PSSALRE expression is in all human tissues and cell lines tested. The the CDK5 gene is mapped to chromosome 7q36. Cyclin-dependent kinase-5 is predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau. CDK5 is required for proper development of the mammalian central nervous system. To be activated, CDK5 must associate with its regulatory subunit, p35(CDK5R1). CDK5 can phosphorylate DARPP32 at threonine-75, converting it into an inhibitor of PKA.
应用类型
WB
免疫原
A synthetic peptide corresponding to a sequence at the C-terminus of human Cdk5(273-292aa QRISAEEALQHPYFSDFCPP), identical to the related rat and mouse sequence.
