ITGAE(INTEGRIN, ALPHA-E), also known as CD103, is an integrin protein that in human is encoded by the ITGAE gene. The ITGAE gene is mapped to chromosome 17p13 by inclusion within a BAC contig. ITGAE is expressed widely on intraepithelial lymphocyte(IEL) T cells(both alphabeta T cells and gammadelta T cells) and on some peripheral regulatory T cells(Tregs) which is important for decreasing the immune response and appears to play a crucial role in the prevention of autoimmune diseases. ITGAE shares overall homology with other alpha integrins but has a unique 55-amino acid "extra" region located just N-terminal to the I domain that contains 18 consecutive charged residues and a proteolytic cleavage site.
应用类型
ELISA,IHC
免疫原
E.coli-derived mouse CD103/Itgae recombinant protein (Position: F20-E1061).
