- 中文名称
Lipase Fluorometric Test Kit, Hepatic, BioAssay
- 英文名字
- Lipase Fluorometric Test Kit, Hepatic, BioAssay
- 供应商
- USBiological
- 产品货号
- L2496-17
- 产品报价
- ￥1/24Tests
- 产品说明书
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- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！
- 产品描述
- Fluorometric tests for the analysis of triglyceride hydrolysis capacity in postheparin plasma (PHP)and tissue culture fluids/ cell extracts.Two lipases are involved in the catabolism of triglyceriderich lipoproteins: lipoprotein lipase (LPL; EC 3.1.1.34) located on glucosaminoglycan chains, anchored to the luminal surface of the capillary epithelium in adipose tissue, heart and skeletal muscle; hepatic lipase (HL; EC3.1.1.3) which is almost exclusive to the endothelial cells of the liver. Both lipases are triglyceride lipases [1]. LPL is a multifunctional protein with a central role in homeostasis and a rate-limiting enzyme for the metabolism of triglyceride-rich chylomicrons and VLDL. Triglycerides of chylomicrons and very low density lipoprotein (VLDL) are the preferred substrates of LPL. An inherited deficiency ofLPL causes defective chylomicron metabolism [1]. Patients with autosomal recessive LPL defects show the symptoms of chylomicronemia and type I hyperlipidemia [2]. Heterozygote LPL deficiency has been identified as a defect of some cases of familial combined hyperlipidemia, one of the most common causes of genetic hyperlipidemia [3]. Many metabolic disorders such as diabetes, obesity, insulin resistence, hyperinsulinemia, hypothyroidism, gestational hyperlipidemia, and renal disease as well as alcohol ingestion are associated with elevated plasma triglycerides. The lipid abnormalities in these diseases can be explained as modulated or changed by LPL activity [4,5]. HL hydrolyses the triglycerides of intermediate density lipoprotein (IDL) and high density lipoprotein-2 (HDL2) [6-9]. It was further shown that the hepatic removal of chylomicron remnants is primarily mediated by mechanisms involving HL (and apolipoprotein E). After the chylomicron remnant particles have bound to the hepatocyte surface, endocytosisispredominantly mediated by the hepatic LDL receptor and at a slower rate by the LDL receptor-related protein (LRP) which is regulated by the receptor-associated protein (RAP) [10]. LPL and HL have been shown to bind directly to LRP [11]. HL and LPL should, therefore, be an important determinant of lipoprotein receptor pathways [12]. Retention of lipoproteins by the extracellular matrix may be another process modulated by the lipases [13]. As the affinity of lipases for heparin is higher than the heparin- sulfate-like anchor, injection of an intravenous heparin bolus displaces both enzymes into postheparin plasma (PHP), where their activity can be quantified. The Total Lipase Test can also be used to determine the activity of bacterial lipases (data available for Pseudomonas lipase).
- 产品特点
- 针对Lipase Fluorometric Test Kit, Hepatic, BioAssay该产品的特点优势，欢迎查阅官网提供的产品说明书。
- 保存建议
- 建议收到Lipase Fluorometric Test Kit, Hepatic, BioAssay产品后将其置于4°C保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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