- 中文名称
腺苷脱氨酶（ADA1）抑制剂筛选试剂盒（比色）
- 英文名字
- Adenosine Deaminase (ADA1) Inhibitor Screening Kit (Colorimetric)
- 供应商
- Biovision
- 产品货号
- K993-100
- 产品报价
- ￥询价/100assays
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868.
- 产品新闻
- 背景资料
- 待更新
- 产品描述
- Adenosine Deaminase (ADA, E.C. 3.5.4.4.) is an enzyme that catalyzes the conversion of adenosine and 2’-deoxyadenosine to inosine and 2’-deoxyinosine. Adenosine is a metabolite that plays important roles in determining cell proliferation, cell cycle progression, and immunosuppressive activation. Although multiple pathways exist for the production of adenosine, its deamination is irreversible, and becomes a critical point in purine metabolite signaling. Both adenosine and inosine bind the adenosine A2A receptor yet can trigger different downstream signaling. Excess adenosine in penile tissue contributes to the disorder called priapism, and impaired adenosine signaling is associated with erectile dysfunction. For this reason, substantial work has gone into identification of inhibitors that would be of clinical relevance. The major isoform of adenosine deaminase, ADA1, is widely expressed in most cells in humans, particularly in lymphocytes and macrophages. ADA1 is present in the cytosol, nucleus and found associated with dipeptidyl peptidase-4 on the cell membrane while ADA2 was first found in the spleen but is predominantly found in the plasma and serum. Adenosine signaling is part of the immune response, and has been shown to reduce T-cell activation. Adenosine Deaminase activity is thus a marker for T-lymphocyte proliferation. BioVision’s Adenosine Deaminase (ADA1) Inhibitor Screening Kit includes the larger 41 kDa form, human ADA1. In BioVision’s ADA inhibitor screening kit, adenosine is deaminated by ADA1 forming inosine. This intermediate is converted to uric acid by a series of enzymatic reactions. The formed uric acid can be measured in the supplied U.V. transparent plate at OD 293 nm. A highly specific ADA1 inhibitor is included as a positive control for inhibition. The kit provides a rapid, simple, sensitive, and reliable test, suitable for high-throughput screening of ADA1 inhibitors.
- 产品特点
- • Rapid, and convenient • The kit screens potential human Adenosine Deaminase Inhibitors
- 保存建议
- -20
- 其他
- BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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