- 中文名称
【干冰】TUMOR SUPPRESSOR PROTEIN ANTIBODY SAMPLER KIT - K913
- 英文名字
- 【干冰】TUMOR SUPPRESSOR PROTEIN ANTIBODY SAMPLER KIT - K913
- 供应商
- Rockland
- 产品货号
- K913
- 产品报价
- ￥询价/1Kit
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- p130, Retinoblastoma-like protein 2 (Rb2), is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. p130 recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation and probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. It is a potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. It binds to cyclins A and E as well as binds to and may be involved in the transforming capacity of the adenovirus E1A protein.
p16, Cyclin Dependent Kinase Inhibitor 2A (CDK2NA), generates several transcripts/proteins which differ from each other in their first exons. In spite of the structural and some functional differences, all the proteins encoded by the CDKN2A gene are capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
p27, p27Kip is a cyclin-dependent kinase inhibitor that shares a limited similarity with CDK inhibitor CDKN1A/p21. p27 binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
- 产品描述
- Each kit contains one unit of the following products:
(100 µL) p/n 100-401-173 Anti-p130 (Rb2) (RABBIT) Antibody
(100 µL) p/n 100-401-170 Anti-p16 (RABBIT) Antibody
(100 µL) p/n 100-401-172 Anti-p27 (RABBIT) Antibody
(100 µg) p/n 611-1322-0100 Anti-RABBIT IgG (H&L) (GOAT) Antibody Peroxidase Conjugated
- 产品特点
- 该【干冰】TUMOR SUPPRESSOR PROTEIN ANTIBODY SAMPLER KIT - K913的详细信息查看Rockland提供的产品说明书。
- 保存建议
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- 其他
- Rockland成立于1962年，是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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