Forkhead box protein P3 (FOXP3) is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). BioVision’s FOXP3 ELISA kit is a sandwich ELISA assay for the quantitative measurement of human FOXP3 in serum, plasma and cell culture supernatants. The density of color is proportional to the amount of FOXP3 captured from the samples.
产品特点
Easy, convenient and time-saving method to measure the level of FOXP3 in human serum, plasma, tissue homogenates, culture supernatants and other biological fluids.
Detection Range: 0.313 – 20 ng/ml
Sensitivity: < 0.188 ng/ml
