Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. BioVision’s SMAD3 ELISA kit is a sandwich ELISA assay for the quantitative measurement of human SMAD3 in serum, plasma and cell culture supernatants. The density of color is proportional to the amount of SMAD3 captured from the samples.
产品特点
Easy, convenient and time-saving method to measure the level of SMAD3 in serum, plasma, tissue homogenates, culture supernatants and other biological fluids.
Detection Range: 0.625 - 40 ng/ml
Sensitivity: < 0.375 ng/ml
