- 中文名称
c-Src激酶抑制剂筛选试剂盒
- 英文名字
- c-Src Kinase Inhibitor Screening Kit
- 供应商
- Biovision
- 产品货号
- K2015-100
- 产品报价
- ￥询价/100assays
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868.
- 产品新闻
- 背景资料
- 待更新
- 产品描述
- Cellular Src Kinase (c-Src, EC 2.7.10.2) is a non-receptor tyrosine kinase that regulates a wide array of cellular signal transduction pathways by phosphorylation of specific tyrosine residues in other tyrosine kinases. Src kinase family members interact with many proteins such as receptor tyrosine kinases, GPCRs, ion channels, steroid receptors, transcription activators, solute transporters and transmembrane adhesion receptors. c-Src was the first “proto-oncogene” to be identified. Over-expression of wild type c-Src or expression of a constitutively active mutant form is frequently found in a number of different cancers. Activation of c-Src enhances angiogenesis, proliferation and invasion pathways in tumors. The extent of this activation typically correlates with the malignant potential and patient survival. Despite the significant role of c-Src in oncogenesis, there are no known selective c-Src inhibitors. A number of clinically used tyrosine kinase inhibitors are capable of inhibiting c-Src. However, the currently available drugs are not selective and inhibit multiple kinases. Selective c-Src inhibitors may be more efficacious and can exhibit fewer side effects than the promiscuous multi-kinase inhibitors. BioVision’s c-Src Kinase Inhibitor Screening Kit enables rapid screening of test compounds for modulation of c-Src activity. The assay uses a c-Src-specific polypeptide substrate and a high concentration of the ultra-pure ATP that closely reflects the physiological ATP levels. ADP formation during the kinase reaction is measured. The strong and stable fluorescence signal (Ex/Em = 535/587 nm) generated during the reaction is directly proportional to the amount of ADP generated. This ensures a high signal-to-background ratio and a little interference due to short wavelength fluorescence by test compounds. The assay is simple, highly sensitive and is high-throughput adaptable. The kit contains a complete set of reagents sufficient for performing 100 reactions in a 96-well plate format.
- 产品特点
- Simple, Rapid screening of test compounds for modulation of c-Src activity, High-throughput adaptable, Highly sensitive
- 保存建议
- -80
- 其他
- BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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