- 中文名称
磷酸烯醇式丙酮酸羧激酶1抑制剂筛选试剂盒
- 英文名字
- Phosphoenolpyruvate Carboxykinase 1 Inhibitor Screening Kit
- 供应商
- Biovision
- 产品货号
- K2012-100
- 产品报价
- ￥询价/100assays
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868.
- 产品新闻
- 背景资料
- 待更新
- 产品描述
- Phosphoenolpyruvate Carboxykinase (PEPCK, EC 4.1.1.32) is an enzyme, which belongs to the lyase family. In the presence of GTP, it catalyzes the reversible conversion of oxaloacetate (OAA) into phosphoenolpyruvate (PEP), GDP and CO2. In humans, two isoforms of PEPCK are found: cytosolic form (PEPCK-C, PEPCK1 or PCK1) and mitochondrial form (PEPCK-M). PEPCK1 is a rate-controlling step in gluconeogenesis and a key gluconeogenic enzyme in liver and kidney. Recent studies have shown that overexpressing of PEPCK1 in liver leads to excessive glucose production and type II diabetic phenotype in mice. Therefore, identifying and screening PEPCK1 inhibitors is a useful strategy for the treatment of type II diabetes and obesity. In BioVision’s Human Phosphoenolpyruvate Carboxykinase 1 Inhibitor Screening Kit, PEPCK1 is coupled with a set of enzymes that covert PEP and carbonate into a series of intermediates and hydrogen peroxide, which in turn reacts with a probe thereby generating a colorimetric signal (OD 570 nm). In the presence of PEPCK1 Inhibitor, the reaction is impeded. A PEPCK1 Inhibitor Control is included to compare the efficacy of the sample inhibitors. The assay is high-throughput adaptable and can be completed in less than 1 hr.
- 产品特点
- High-throughput adaptable, Simple, Quick
- 保存建议
- -20
- 其他
- BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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