- 中文名称
醛糖还原酶抑制剂筛选试剂盒（比色）
- 英文名字
- Aldose Reductase Inhibitor Screening Kit (Colorimetric)
- 供应商
- Biovision
- 产品货号
- K174-100
- 产品报价
- ￥询价/100assays
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868.
- 产品新闻
- 背景资料
- 待更新
- 产品描述
- Aldose Reductase (aldehyde reductase; AR; ALR2; EC 1.1.1.21), a member of the aldo-keto reductase superfamily, catalyzes the NADPH-dependent reduction of a wide variety of aldoses (molecules containing carbonyl groups) to their corresponding alcohols. It is a key enzyme in the polyol pathway and the key factor in the reduction of glucose to sorbitol. Synthesis and accumulation of sorbitol due to AR activity is the main cause of diabetic complications, such as diabetic cataract, retinopathy, neuropathy and nephropathy. Inhibition of AR has been successfully used in clinical settings. These approved drugs prevent the accumulation of sorbitol. Thus, preventing eye and nerve damage in patients with diabetes. In addition, recent studies have shown that AR inhibitors may be able to prevent or delay the onset of cardiovascular complications such as ischemia/reperfusion injury, atherosclerosis and atherothrombosis. BioVision’s Aldose Reductase Inhibitor Screening Kit can be used to screen potential inhibitors of this molecular target. Epalrestat, a noncompetitive AR inhibitor, is used as a Positive Control. In this assay, AR activity is monitored by the reduction in absorbance reading at OD 340 nm, while potential inhibitors arrest this decrease. The kit is adapted to a 96-well format and provides a rapid, simple, sensitive and reliable test for screening of AR inhibitors.
- 产品特点
- Rapid, Simple, Sensitive, Reliable
- 保存建议
- -20
- 其他
- BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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