- 中文名称
HDAC-5抑制剂筛选试剂盒（荧光法）
- 英文名字
- HDAC-5 Inhibitor Screening Kit (Fluorometric)
- 供应商
- Biovision
- 产品货号
- K171-100
- 产品报价
- ￥询价/100assays
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868.
- 产品新闻
- 背景资料
- 待更新
- 产品描述
- Histone Deacetylase 5 or HDAC-5 belongs to Class II Histone deacetylase family. It represses transcription by deacetylating lysine residues on the N-terminal part of histones H2A, H2B, H3 and H4. This epigenetic repression caused by HDAC-5, plays a role in transcriptional regulation, cell cycle progression and development. It interacts with myocyte enhancing factor (MEF-2) proteins that are associated with colon cancer, causing the repression of MEF-2 dependent gene expression. HDAC-5 is also involved in epigenetic regulation of ESR1 expression in breast cancer. HDAC-5 inhibition induces reactive oxygen species (ROS) production, ultimately leading to apoptotic cell death as well as mechanisms of mitochondrial quality control processes such as mitophagy and mitobiogenesis. Therefore, HDAC-5 inhibition in cancer cells significantly reduces tumor size due to apoptotic cell death of cancer cells (Hendrick, et al, Oncogene. 2017 Aug 24; 36(34):4859-4874), which makes HDAC-5 an attractive target for anti-cancer therapy. BioVision’s HDAC-5 Inhibitor Screening Kit is a plate-based fluorometric kit for screening potential HDAC-5 inhibitors. The principle of the kit is based on the deacetylation of an acetylated substrate by HDAC-5. The deacetylated product is then cleaved by a developer to release a highly fluorescent moiety with Ex/Em= 380/460 nm. Trichostatin A, a well-known HDAC inhibitor is provided as inhibitor control.
- 产品特点
- • Simple and reliable test to screen/study/characterize HDAC5 inhibitors
• High-throughput compatible
• Includes Inhibitor Control (Trichostatin A)
- 保存建议
- -80
- 其他
- BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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