12 G5特异性结合表达重组CXCR 4的人和非人细胞。12 G5抑制一些HIV-2分离株的CD 4非依赖性感染，并且用12 G5预孵育细胞消除合胞体形成。HIV-2/vcp感染的细胞显示12 G5结合的显著和选择性降低。12 G5还抑制HIV-1和HIV-2株诱导CXCR 4 + RD/CD 4细胞的细胞间融合。 原液抗人CXCR4（12G5）抗体该产品同种型对照：Mouse IgG2a In Vivo Isotype Control – Low Endotoxin (C1.18.4) [ICH2245] 缓冲液：ICH3001-100ml，nICH3002-100ml，nICH3003-100ml， 浓度：≥ 2.0 mg/ml 纯度：>95% by SDS-PAGE 内毒素：<1.0 EU/mg as determined by the LAL method 制剂：Sterile, preservative-free, solution in PBS. BSA and Azide free.
应用类型
Blocking, Flow Cytometry, Immunocytochemistry, Immunofluorescence Microscopy, Immunohistochemistry, Neutralization, Western Blotting
免疫原
12G5 was produced by immunizing Balb/c mice with CP-MAC-infected Sup-T1 cells. Hybridomas were generated and screened for the ability to inhibit CP-MAC-induced syncytium induction on Sup-T1 cells.
