CCR 5抗体HEK/1/85 a/7a识别C-C趋化因子受体5型(CCR 5),也称为CD 195、CC-CKR-5、CHEMR 13和HIV-1融合辅助受体。CCR 5是一种45 kDa的七跨膜G蛋白偶联受体(GPCR)。CCR 5在记忆T细胞、巨噬细胞和未成熟树突状细胞(DC)的亚群上表达,并被促炎细胞因子上调。CCR 5与炎性CC-趋化因子结合,包括CCL 3(巨噬细胞炎性蛋白(MIP)-1α)、CCL 4(MIP-1β)和RANTES,其增加细胞内钙水平并导致细胞骨架重排和趋化细胞迁移。CCR 5也是HIV-1的辅助受体,在病毒gp 120与CD 44 -7结合后。细胞上CCR 5的水平影响HIV-1的进入率,CCR 5水平较低的患者表现出抗感染的免疫力。CCR 5还导致其他人类疾病,包括I型糖尿病和癌症。 Bulk Anti-Human CD 195(HEK/1/85 a/7a)Antibody(CCR 5)-超低内毒素该产品同种型对照:Rat IgG2b In Vivo Isotype Control - Low Endotoxin [1-2] (ICH2243) 缓冲液:ICH3001-100ml,nICH3002-100ml,nICH3003-100ml, 浓度:≥ 5.0 mg/ml 纯度:>98% by SDS-PAGE and HPLC 内毒素:≤ 0.5 EU/mg as determined by the LAL method 制剂:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
应用类型
Flow Cytometry, ImmunoCytochemistry
免疫原
CHO cells transfected with full-length human CD195 (CCR5).