IL-1结合两种受体,IL-1 RI和IL-1 RII。配体IL-1 α和IL-1 β通过结合IL-1 RI发挥它们所有的各种生物学作用。IL-1 RII具有缩短的胞质结构域,其不能阻断信号,因此充当诱饵受体并竞争性拮抗IL-1 α和IL-1 β的结合,从而降低其生物学效应。辅助蛋白IL-1 R-AcP可增强配体与IL-1 RI的结合。IL-1 RI在T细胞、胸腺细胞、树突状细胞、成纤维细胞、血管内皮细胞、上皮细胞和神经细胞上表达。它是一种80 kD的跨膜糖蛋白。 抗小鼠IL-1 R(JAMA-147)体内抗体-低内毒素该产品同种型对照:Armenian Hamster IgG Isotype Control for In Vivo - Low Endotoxin [PIP] (ICH2251) 缓冲液:ICH3001-100ml,nICH3002-100ml,nICH3003-100ml, 浓度:1.0 - 5.0 mg/ml 纯度:>95% by SDS-PAGE and HPLC 内毒素:≤ 1.0 EU/mg as determined by the LAL method 制剂:0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
应用类型
Immunoprecipitation, Western Blot, Blocking, Flow Cytometry