RANKL(Receptor Activator for Nuclear Factor κ B Ligand),又称肿瘤坏死因子相关活化诱导细胞因子(TRANCE)、骨保护素配体(OPGL)和破骨细胞分化因子(ODF),是肿瘤坏死因子家族细胞因子的一员。RANKL对破骨细胞的形成、活化和存活至关重要。RANKL通过与其受体RANK相互作用可调节基质降解和炎症。RANKL和RANK在妊娠期间淋巴结形成、胸腺微环境的建立和泌乳乳腺的发育中具有重要作用。因此,特异性靶向破骨细胞中RANK、RANKL及其信号通路的新型药物有望彻底改变与骨丢失相关的各种疾病的治疗,如关节炎、牙周病、癌症转移和骨质疏松症。 抗小鼠RANKL(IK 22/5)体内抗体-超低内毒素该产品同种型对照:Rat IgG2a In Vivo Isotype Control - Low Endotoxin [1-1] (ICH2244) 缓冲液:ICH3001-100ml,nICH3002-100ml,nICH3003-100ml, 浓度:1.0 mg/ml 纯度:>98% by SDS-PAGE and HPLC 内毒素:≤ 0.5 EU/mg as determined by the LAL method 制剂:0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
应用类型
Flow Cytometry, Immunoprecipitation, Western Blot, Blocking, Immunofluorescence, IHC (Frozen)