HSPB3 is a muscle-specific small heat shock protein which is expressed specially in heart and skeletal muscle. Mammalian small heat shock proteins （sHSP） are highly expressed proteins with varied roles， including the assembly and impounding of multi-protein complexes， transportation of nascent polypeptide chains thru cellular membranes and regulation of protein folding. HSPB3 perform as an ATP-dependent chaperone protein which takes part in the refolding of denatured proteins and inhibition of actin polymerization.
