HSPB8 displays temperature-dependent chaperone activity. HSPB8 acts as a mn（2+）-dependent serine-threonine- specific protein kinase. we are not convinced that this is its true role. Defects in HSPB8 are a cause of distal hereditary motor neuropathy type ii （DHMN2） also known as distal spinal muscular atrophy （DSMA） and spinal muscular atrophy of the charcot-marie-tooth type. it is an autosomal dominant disorder of lower motor neurons characterized by distal muscle weakness.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered White lyophilized （freeze-dried） powder. The HSPB8 protein was lyophilized from a concentrated （1mg/ml） solution containing 20mM Tris-acetate， pH-7.6， 10mM NaCl， 0.1mM EDTA， 0.1mM PMSF， 15mM ?-ME. It is recommended to reconstitute the lyophilized HSPB8 in sterile 18M?-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.
保存建议
Lyophilized HSPB8 although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution HSPB8 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
